You will not encounter any serious drawbacks. TexturePacker is very easy to use and it takes less than a minute to create a sprite sheet. It allows you to make numerous adjustments, to sort your sprites however you want and to prepare them for various game engines.
The software is capable of arranging sprites on a sheet automatically. You can also make a series of layout adjustments, like sorting the sprites by name, height, width or other criteria, ascending or descending, or set different border and shape padding levels. It is possible to select different size constraints, depending on your hardware's capabilities, to scale the sheet and more. Other adjustments can be made in the same area of the interface. For example, you may convert your sprites from RGBA8888 to RGBA4444 and apply a dithering method. TexturePacker allows you to reduce their colors, without sacrificing too much from their quality. Certain images use a large amount of memory, causing a game to run slower. While making your output settings, you may select one of many game engines, texture and image formats, DPI levels and more. You can save your sprite sheet right away, but you can also make a wide range of adjustments on the left side of the window. Once the images are loaded, the software will automatically arrange them on a sheet, in the central region of the interface. You can load your images in PNG, PSD, SWF or other formats with an Open dialog or by dragging and dropping them on the right side of the interface. If you are a games development blogger or you develop your own open source game frameworks, you can have the software for free.
You have to buy a license if you want to enjoy the software's entire array of features, but you can test it for one week, without any restrictions. You can also make numerous settings, to prepare your sprites for almost any game engine. You just need to load your pictures and the software will arrange them automatically. TexturePacker can be used to create sprite sheets, without any effort. Instead of managing countless files, you should create a sprite sheet, to make your work easier. If developing 2D games is part of your daily routine, then you probably have a large sprite collection, which is not easy to organize.